MAIL, a novel nuclear IκB protein that potentiates LPS‐induced IL‐6 production
- 14 November 2000
- journal article
- Published by Wiley in FEBS Letters
- Vol. 485 (1), 53-56
- https://doi.org/10.1016/s0014-5793(00)02185-2
Abstract
We have identified and characterized a novel member of the ankyrin-repeat family named ‘molecule possessing ankyrin-repeats induced by lipopolysaccharide’ (MAIL). The C-terminal portion of MAIL shared high sequence homology with the IκB family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (<0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells. These findings indicate that MAIL is one of the nuclear IκB proteins and an activator of IL-6 production.Keywords
This publication has 18 references indexed in Scilit:
- The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B CellsThe Journal of Experimental Medicine, 2000
- Bcl3, an IκB Protein, Stimulates Activating Protein-1 Transactivation and Cellular ProliferationJournal of Biological Chemistry, 1999
- Bcl3, an IκB Protein, as a Novel Transcription Coactivator of the Retinoid X ReceptorPublished by Elsevier BV ,1998
- Adrenomedullin Stimulates Interleukin-6 Production in Swiss 3T3 CellsBiochemical and Biophysical Research Communications, 1998
- Diverse Effects of BCL3 Phosphorylation on Its Modulation of NF-κB p52 Homodimer Binding to DNAJournal of Biological Chemistry, 1997
- Immunological defects in mice with a targeted disruption in Bcl-3.Genes & Development, 1997
- Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cellsFEBS Letters, 1996
- Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide.Molecular and Cellular Biology, 1994
- The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodiesEuropean Journal of Immunology, 1988