Adherence to controller therapy for chronic obstructive pulmonary disease: a review
- 16 August 2010
- journal article
- research article
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 26 (10), 2421-2429
- https://doi.org/10.1185/03007995.2010.516284
Abstract
While several studies have examined adherence to controller medications for the treatment of COPD, few systematic reviews have taken the translational step to identifying important and necessary areas for further research. The objective of this study was to review data on the outcomes of adherence to various controller therapies in patients with COPD in an effort to help prescribers understand adherence properties for each therapy. This is a systematic review of studies investigating adherence to an array of controller pharmaceutical regimens. The studies were obtained from PubMed during 2008 and 2009 using the following key words: chronic obstructive pulmonary disease, COPD, adherence, controller medication, and persistence. Only articles encompassing adherence or persistence data to controller medications and published after 1990 were utilized. After the search results were filtered for only the articles that pertained to adherence or persistence measurements in COPD, 35 articles remained; and finally, discounting those articles not published in English, articles which did not compare treatments for COPD, as well as those which were review articles, ten applicable articles remained. Each of these found low levels of medication adherence and/or persistence among patients receiving medications for COPD. Patients receiving fluticasone/salmeterol (FSC) and tiotropium (TIO) for treatment showed the highest adherence among all controller medications. Patients who were married, older, and white were more likely to adhere to their medications. Characteristics of the medication used (i.e. dosing schedule, formulation, etc.) as well as patient characteristics affect the adherence/persistence to medications for the treatment of COPD. Further patient education is necessary in order to effectively improve disease management and patient outcomes in COPD. There is a need for future research and educational efforts to improve adherence in COPD and more clearly identify specific behavioral and treatment characteristics associated with specific COPD medications that can facilitate adherence.Keywords
This publication has 19 references indexed in Scilit:
- Adherence to inhaled therapy, mortality and hospital admission in COPDThorax, 2009
- Medication Adherence: A Review of the Literature and Implications for Clinical PracticeJournal of Psychiatric Practice, 2009
- Two Pharmacy Interventions to Improve Refill Persistence for Chronic Disease MedicationsMedical Care, 2009
- Healthcare use and costs in patients with chronic bronchitis initiating maintenance therapy with fluticasone/salmeterol vs other inhaled maintenance therapiesCurrent Medical Research and Opinion, 2008
- Adherence to treatment by patients with asthma or COPD: Comparison between inhaled drugs and transdermal patchRespiratory Medicine, 2007
- Salmeterol and Fluticasone Propionate and Survival in Chronic Obstructive Pulmonary DiseaseThe New England Journal of Medicine, 2007
- Acute Exacerbations of Chronic Bronchitis in Elderly PatientsDrugs & Aging, 2007
- Adherence and persistence with fluticasone propionate/salmeterol combination therapyJournal of Allergy and Clinical Immunology, 2006
- Suboptimal Medical Therapy in COPDSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2000
- Compliance During Long-Term Treatment with Fluticasone Propionate in Subjects with Early Signs of Asthma or Chronic Obstructive Pulmonary Disease (COPD): Results of the Detection, Intervention, and Monitoring Program of COPD and Asthma (DIMCA) StudyJournal of Asthma, 2000