Solitary adult xanthogranuloma in external auditory canal: Cyto-histopathological correlation of an uncommon entity at an uncommon site
- 1 July 2020
- journal article
- research article
- Published by Wiley in Diagnostic Cytopathology
- Vol. 48 (7), 666-669
- https://doi.org/10.1002/dc.24430
Abstract
Juvenile xanthogranulomas (JXG) are the most common type of self-limiting non-Langerhans cell histiocytosis (LCH) usually presenting in infancy and early childhood. Clinically, they present as solitary to multiple rounded cutaneous nodules which resolve over time. Adult type xanthogranulomas (AXG), though histologically similar to JXG, are usually single and do not regress spontaneously. AXG arising in the external auditory canal (EAC) is a rare occurrence with very few cases reported in literature. We present a case of AXG in a 48-year-old man, arising from the right EAC. This case is unique as it is the only case to be described with both cytology and histology correlation. On cytology, smears showed scattered foamy histiocytes, inflammatory cells and thick stromal fragments. Cytology differential diagnoses of xanthomatous lesion, benign fibrous histiocytoma (BFH) and ceruminous adenoma were given; final diagnosis was deferred to histopathology which confirmed it to be an AXG. Thus, it is important to keep the diagnosis of AXG in mind while dealing with solitary polypoidal lesions in EAC showing prominent foam cell component. Lipidised BFH forms a close differential diagnosis, however can be excluded by subtle points on cytology and on histopathology.Keywords
This publication has 18 references indexed in Scilit:
- Xanthogranuloma of the External Auditory Canal Mimicking a Benign Tumor: A Case ReportCase Reports in Otolaryngology, 2012
- Multiple generalized xanthogranuloma in adult: Case report and treatmentIndian Journal of Dermatology, 2011
- Fine Needle Aspiration Cytology of Benign Fibrous Histiocytoma of BoneActa Cytologica, 2010
- Cutaneous fibrohistiocytic tumours – an updateHistopathology, 2009
- Cytology of soft tissue tumors: Benign soft tissue tumors including reactive, nonneoplastic lesionsJournal of Cytology, 2008
- Multiple xanthogranulomas in an adultIndian Journal of Dermatology, Venereology and Leprology, 2008
- Clonality in Juvenile XanthogranulomaThe American Journal of Surgical Pathology, 2007
- “Juvenile” XanthogranulomaThe American Journal of Dermatopathology, 2001
- Lipidized Fibrous HistiocytomaThe American Journal of Dermatopathology, 2000
- Xanthogranuloma in AdultsArchives of Dermatology, 1976