Current therapy of acute uncomplicated cystitis
- 23 April 2010
- journal article
- review article
- Published by Wiley in International Journal of Urology
- Vol. 17 (5), 450-456
- https://doi.org/10.1111/j.1442-2042.2010.02500.x
Abstract
Acute uncomplicated cystitis (AUC) is one of the most common bacterial urinary tract infections. AUC frequently occurs in young sexually active, as well as postmenopausal, women. According to the guidelines published by the Infectious Diseases Society of America in 1999, the standard antimicrobial regimen for treatment of AUC is 3 days with trimethoprim-sulfamethoxazole (TMP/SMX); however, today the most popular antibiotics are the fluoroquinolones because of the emergence of uropathogens that are resistant to TMP/SMX. Fluoroquinolone resistance is also increasing worldwide, although the resistance rates have not been as high as those for TMP/SMX. Extended-spectrum beta-lactamase (ESBL)-producing strains are another problem because most nosocomial ESBL producers are also resistant to non-beta-lactams, such as the fluoroquinolones. Under such circumstances, 3 days of therapy with fluoroquinolones or 7 days with beta-lactams is recommended for empirical therapy, although these regimens should be re-evaluated in the next decade. Low-dose fluoroquinolones should no longer be used because of the potential for emergence of resistance.Keywords
This publication has 39 references indexed in Scilit:
- Genetic Profiles of Fluoroquinolone-Resistant Escherichia coli Isolates Obtained from Patients with Cystitis: Phylogeny, Virulence Factors, PAI usp Subtypes, and Mutation PatternsJournal of Clinical Microbiology, 2009
- European Emergence of Ciprofloxacin-Resistant Escherichia coli Clonal Groups O25:H4-ST 131 and O15:K52:H1 Causing Community-Acquired Uncomplicated CystitisJournal of Clinical Microbiology, 2008
- Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates, London 2005 – 2006Annals of Clinical Microbiology and Antimicrobials, 2008
- Risk Factors for Trimethoprim-Sulfamethoxazole Resistance in Patients with Acute Uncomplicated CystitisAntimicrobial Agents and Chemotherapy, 2008
- Short-term therapy for urinary tract infection: success and failureInternational Journal of Antimicrobial Agents, 2008
- Escherichia coli from Urine of Female Patients with Urinary Tract Infections Is Competent for Intracellular Bacterial Community FormationInfection and Immunity, 2007
- Antimicrobial Resistance of Urinary Tract Isolates in Acute Uncomplicated Cystitis Among College-Aged Women: Choosing a First-Line TherapyJournal of American College Health, 2007
- Clinical relevance of laboratory-reported antibiotic resistance in acute uncomplicated urinary tract infection in primary careJournal of Antimicrobial Chemotherapy, 2006
- Multicenter Antimicrobial Susceptibility Survey of Gram-Negative Bacteria Isolated from Patients with Community-Acquired Infections in the People's Republic of ChinaAntimicrobial Agents and Chemotherapy, 2006
- A Controlled Trial of Intravaginal Estriol in Postmenopausal Women with Recurrent Urinary Tract InfectionsNew England Journal of Medicine, 1993