Adrenarche and Fetal Growth
- 1 March 1997
- journal article
- Published by Springer Science and Business Media LLC in Pediatric Research
- Vol. 41 (3), 440-442
- https://doi.org/10.1203/00006450-199703000-00023
Abstract
Dehydroepiandrosterone sulfate (DHEAS) is prenatally secreted by the fetal adrenal, is an indicator of adrenarche from late childhood onward and is a marker of the individual hormonal milieu in the adult. The regulation of DHEAS secretion is still poorly understood. We postulated that serum DHEAS concentrations in children may be related to fetal growth. To test this hypothesis, serum DHEAS was measured at a median age of 8.2 y (range 5.8-16.0 y) in 13 pairs of discordant siblings after twin (n = 8), triplet(n = 4), or quadruplet (n = 1) pregnancy. At birth, one of each pair was small for gestational age (SGA) and the other had an appropriate weight (AGA); weight of the smallest infant was a median 67% (range 33-80%) of that of the largest sibling. In all 10 pairs with similar weight (≤ 1 SD difference) at the time of sampling, serum DHEAS concentration in the SGA child was higher (median 2-fold increase; range 1.1-7; p = 0.002) than in the AGA sibling. Conversely, in the 3 pairs with still discordant weight (>2 SD difference), serum DHEAS levels in SGA children were lower than in AGA children. In conclusion, the presented findings, which account for both prenatal and postnatal weight gain, unmask a link between adrenarche and fetal growth. This relationship further supports the concept of early endocrine “programming” and extends this principle to adrenarche.Keywords
This publication has 11 references indexed in Scilit:
- The zona reticularis is the site of biosynthesis of dehydroepiandrosterone and dehydroepiandrosterone sulfate in the adult human adrenal cortex resulting from its low expression of 3 beta- hydroxysteroid dehydrogenaseJournal of Clinical Endocrinology & Metabolism, 1996
- Dehydroepiandrosterone (DHEA): a fountain of youth?Journal of Clinical Endocrinology & Metabolism, 1996
- Dehydroepiandrosterone sulphate in critical illness: effect of dopamineClinical Endocrinology, 1995
- Serum dehydroepiandrosterone sulfate levels as an individual markerJournal of Clinical Endocrinology & Metabolism, 1994
- Fetal nutrition and cardiovascular disease in adult lifeThe Lancet, 1993
- Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growthDiabetologia, 1993
- Modelling of Reference Values for Size at BirthActa Paediatrica, 1989
- Anorexia nervosa and the adrenal: The effect of weight gainJournal of Psychiatric Research, 1985
- Secretion of the adrenal androgen, dehydroepiandrosterone sulfate, during normal infancy, childhood, and adolescence, in sick infants, and in children with endocrinologic abnormalitiesThe Journal of Pediatrics, 1977
- Serum Dehydroepiandrosterone Sulfate in Premature Infants and Infants with Intrauterine Growth RetardationJournal of Clinical Endocrinology & Metabolism, 1976