Thin-Film Microbiosensors for Glucose−Lactate Monitoring
- 1 January 1996
- journal article
- clinical trial
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 68 (18), 3173-3179
- https://doi.org/10.1021/ac950630x
Abstract
A miniaturized device for simultaneous measurement of glucose and lactate levels was produced by means of photopatterning of enzyme-containing photosensitive membrane precursors. This device shows no cross-talk and a lifetime for both the glucose and the lactate sensors of more than 2 weeks when continuously operated in undiluted bovine serum. Linear response ranges of up to 40 mM for glucose and 25 mM for l-lactate, in combination with 95% response times of 0.98 with respect to laboratory techniques. Subcutaneous measurements of glucose levels in pigs were close to the corresponding blood levels obtained without in vivo calibration.Keywords
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