Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Top Cited Papers
- 1 July 2016
- journal article
- research article
- Published by Elsevier BV in Cancer Cell
- Vol. 30 (1), 147-160
- https://doi.org/10.1016/j.ccell.2016.05.016
Abstract
• Short-term fasting improves anticancer chemotherapy • Treatment with caloric restriction mimetics (CRMs) inhibits tumor growth in vivo • CRMs trigger an autophagy-dependent anticancer immune response • CRMs deplete regulatory T Cells from tumor bedKeywords
Funding Information
- Ligue Nationale Contre le Cancer
- Site de Recherche Intégrée sur le Cancer (IRIC) Socrates
- ISREC Foundation
- Agence Nationale pour la Recherche
- European Commission
- European Research Council Advanced Investigator
- Fondation pour la Recherche Médicale
- Institut National Du Cancer
- Fondation de France
- Cancéropôle Ile-de-France
- Fondation Bettencourt-Schueller
- Labex Immuno-Oncology
- Paris Alliance of Cancer Research Institutes
- EU Network
- Apo-Sys ApoSys and InflaCare
- ERC
- DoD Innovator Award
- LIPOTOX (P23490-B12, P24381-B20)
- BMWFW
- AIRC (IG5354)
- Telethon (GGP06070)
- ERA-NET NEURON
- Ministry of Health of Italy (RF-2011-02348435)
- Italian Ministry of Education, University and Research (RBAP11FXBC_001)
- University of Ferrara
- NIH (RO1CA109618, U19 AI109725)
- Cancer Prevention and Research Institute of Texas (RP120718)
- Cancéropôle Ile-de-France
This publication has 52 references indexed in Scilit:
- Autophagy modulation as a potential therapeutic target for diverse diseasesNature Reviews Drug Discovery, 2012
- Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to ChemotherapyScience Translational Medicine, 2012
- CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasisProceedings of the National Academy of Sciences of the United States of America, 2011
- Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteomeThe Journal of cell biology, 2011
- Rapamycin fed late in life extends lifespan in genetically heterogeneous miceNature, 2009
- Tumours with PI3K activation are resistant to dietary restrictionNature, 2009
- Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male miceAging Cell, 2008
- Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane LuciferasePLOS ONE, 2008
- Autophagy fights disease through cellular self-digestionNature, 2008
- Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like diseaseThe Journal of Experimental Medicine, 2007