TREATMENT OF ESSENTIAL HYPERTENSION WITH CHLOROTHIAZIDE (DIURIL)

Abstract

Ten hypertensive patients were hospitalized on a constant intake of sodium chloride until their blood pressure levels had stabilized. Chlorothiazide in amounts of 1.5 Gm. per day reduced the systolic blood pressure in all. The average reduction was 18.7%, it took place within two or three days and was maintained to the end of a six-day period of medication. When it was withdrawn the blood pressure returned to its former level. Chlorothiazide (maintenance dose, 0.5 Gm. twice daily) added to the regimen of 73 ambulatory hypertensive patients who were receiving other antihypertensive drugs as well caused an additional reduction of blood pressure. In some patients it was possible to withdraw all other antihypertensive medication and to maintain the patient on chlorothiazide alone. Most of the patients noted a diuresis the first day or two after treatment with chlorothiazide. It exaggerated postural hypotension when that sign was already present, and reduction of the dosages of ganglion-blocking agents was necessary when chlorothiazide treatment was begun, in order to prevent postural collapse. Chlorothiazide also enhanced the antihypertensive activity of hydralazine, Veratrum, and reserpine. Side-effects were mild and infrequent and were promptly obviated by temporary withdrawal of the drug.