Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326
- 18 April 2011
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (18), 6865-6867
- https://doi.org/10.1021/ja1110688
Abstract
An acinar morphogenesis inhibitor named fusarisetin A (1) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of 1 was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.Keywords
This publication has 16 references indexed in Scilit:
- The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D culturesBMC Cancer, 2010
- The role of collagen reorganization on mammary epithelial morphogenesis in a 3D culture modelBiomaterials, 2010
- Drug Discovery and Natural Products: End of an Era or an Endless Frontier?Science, 2009
- Fractionated Marine Invertebrate Extract Libraries for Drug DiscoveryMolecules, 2008
- Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug DiscoveryJournal of Natural Products, 2008
- Cyclin‐dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesisCell Proliferation, 2007
- Use of Three-Dimensional Basement Membrane Cultures to Model Oncogene-Induced Changes in Mammary Epithelial MorphogenesisJournal of Mammary Gland Biology and Neoplasia, 2004
- Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent mannerThe Journal of cell biology, 2003
- Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesMethods, 2003
- ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial aciniNature, 2001