Lifelong Caloric Restriction Increases Working Memory in Mice
Open Access
- 10 July 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (7), e68778
- https://doi.org/10.1371/journal.pone.0068778
Abstract
Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.This publication has 52 references indexed in Scilit:
- Dietary ketosis enhances memory in mild cognitive impairmentNeurobiology of Aging, 2012
- Behavioral changes in aging female C57BL/6 miceNeurobiology of Aging, 2011
- Exercise training increases size of hippocampus and improves memoryProceedings of the National Academy of Sciences of the United States of America, 2011
- Low Calorie Dieting Increases CortisolPsychosomatic Medicine, 2010
- Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 miceNeuroscience Letters, 2009
- Influence of Calorie Restriction on Measures of Age-Related Cognitive Decline: Role of Increased Physical ActivityThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodiesBrain Research Reviews, 2009
- Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning abilityExperimental Neurology, 2008
- Dietary restriction-induced life extension: a broadly based biological phenomenonBiogerontology, 2006
- Behavioral phenotyping of mice in pharmacological and toxicological researchExperimental and Toxicologic Pathology, 2003