Prevention of aspirin-induced faecal blood loss by prostaglandin E2.
Open Access
- 1 July 1980
- Vol. 21 (7), 602-606
- https://doi.org/10.1136/gut.21.7.602
Abstract
Prostaglandins have been shown in animal laboratory studies to be capable of protecting the gastrointestinal tract against injury by exogenous agents. This study was conducted to determine if prostaglandin E2 (PGE2), which is native to the human gastric mucosa, could influence the increase in faecal blood loss associated with the ingestion of aspirin (ASA). A randomised double-blind study was performed on 27 healthy men. Faecal blood loss was measured by the 51Cr labelled red cell technique. ASA (600 mg four times daily) caused a significant increase in faecal blood loss. PGE2 (1 mg four times daily) had no effect on faecal blood loss when administered alone. When given in addition to ASA it resulted in a faecal blood loss not significantly different from control. No significant alteration in intestinal transit occurred. It is concluded that PGE2 protects man from the gastrointestinal injury associated with ASA.Keywords
This publication has 31 references indexed in Scilit:
- Permeability effects of the E2 prostaglandins on canine gastric mucosaCanadian Journal of Physiology and Pharmacology, 1979
- The effects of a prostaglandin endoperoxide analogue on canine gastric acid and mucus secretionDigestive Diseases and Sciences, 1979
- Effect of 16,16-dimethyl prostaglandin E2 on the gastric mucosal barrier.Gut, 1979
- MUCOSAL PROTECTION BY PROSTAGLANDIN E2The Lancet, 1979
- MUCOSAL CYTOPROTECTION BY PROSTAGLANDIN E2The Lancet, 1978
- DRUG-INDUCED GASTROINTESTINAL BLEEDING: Report from The Boston Collaborative Drug Surveillance Program, Boston University Medical CenterThe Lancet, 1978
- Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandinsDigestive Diseases and Sciences, 1978
- Stimulation of Non-Parietal Cell Secretion in Canine Heidenhain Pouches by 16,16-Dimethyl Prostaglandin E2Digestion, 1978
- Effect of Orally Administered Prostaglandin E2 and its 15-Methyl Analogues on Gastric SecretionBMJ, 1973
- Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin.BMJ, 1967