Formation of dTDP-Rhamnose Is Essential for Growth of Mycobacteria
Open Access
- 15 June 2002
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 184 (12), 3392-3395
- https://doi.org/10.1128/jb.184.12.3392-3395.2002
Abstract
It was determined that the dTDP-rhamnose synthesis gene, rmlD , could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.Keywords
This publication has 22 references indexed in Scilit:
- Cell Wall Core Galactofuran Synthesis Is Essential for Growth of MycobacteriaJournal of Bacteriology, 2001
- Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Genetics of dTDP-Rhamnose Synthetic Enzymes and Development of a Microtiter Plate-Based Screen for Inhibitors of Conversion of dTDP-Glucose to dTDP-RhamnoseAntimicrobial Agents and Chemotherapy, 2001
- The crystal structure of dTDP-d-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar typhimurium, the second enzyme in the dTDP-l-rhamnose pathwayJournal of Molecular Biology, 2001
- Phosphatidylinositol Is an Essential Phospholipid of MycobacteriaPublished by Elsevier BV ,2000
- Purification to Apparent Homogeneity and Properties of Pig Kidneyl-Fucose KinasePublished by Elsevier BV ,1998
- Biosynthesis of the Linkage Region of the Mycobacterial Cell WallPublished by Elsevier BV ,1996
- Major structural features of the cell wall arabinogalactans of Mycobacterium, Rhodococcus, and Nocardia spp.Carbohydrate Research, 1993
- Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatisMolecular Microbiology, 1990
- Use of biotinylated DNA probes in colony hybridizationNucleic Acids Research, 1986
- Biosynthesis of thymidine diphosphate l-rhamnose in Escherichia coli K-12Biochimica et Biophysica Acta (BBA) - General Subjects, 1965