Epicardial fat in heart failure patients with mid‐range and preserved ejection fraction
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Open Access
- 1 August 2018
- journal article
- research article
- Published by Wiley in European Journal of Heart Failure
- Vol. 20 (11), 1559-1566
- https://doi.org/10.1002/ejhf.1283
Abstract
Aims Adipose tissue and inflammation may play a role in the pathophysiology of patients with heart failure (HF) with mildly reduced or preserved ejection fraction. We therefore investigated epicardial fat in patients with HF with preserved (HFpEF) and mid‐range ejection fraction (HFmrEF), and related this to co‐morbidities, plasma biomarkers and cardiac structure. Methods and results A total of 64 HF patients with left ventricular ejection fraction >40% and 20 controls underwent routine cardiac magnetic resonance examination. Epicardial fat volume was quantified on short‐axis cine stacks covering the entire epicardium and was related to clinical correlates, biomarkers associated with inflammation and myocardial injury, and cardiac function and contractility on cardiac magnetic resonance. HF patients and controls were of comparable age, sex and body mass index. Total epicardial fat volume was significantly higher in HF patients compared to controls (107 mL/m2 vs. 77 mL/m2, P 2, P =0.03, and 120 vs. 97 mL/m2, P =0.001, respectively). Creatine kinase‐MB, troponin T and glycated haemoglobin in patients with HF were positively correlated with epicardial fat volume (R =0.37, P =0.006; R =0.35, P =0.01; and R =0.42, P =0.002, respectively). Conclusion Heart failure patients had more epicardial fat compared to controls, despite similar body mass index. Epicardial fat volume was associated with the presence of atrial fibrillation and type 2 diabetes mellitus and with biomarkers related to myocardial injury. The clinical implications of these findings are unclear, but warrant further investigation.Keywords
Funding Information
- Abbott Netherlands
This publication has 33 references indexed in Scilit:
- Pericardial Rather Than Epicardial Fat is a Cardiometabolic Risk Marker: An MRI vs Echo StudyJournal of the American Society of Echocardiography, 2011
- Impact of increased visceral and cardiac fat on cardiometabolic risk and diseaseDiabetic Medicine, 2011
- Epidemiology and clinical course of heart failure with preserved ejection fractionEuropean Journal of Heart Failure, 2011
- Epicardial adipose tissue in patients with heart failureJournal of Cardiovascular Magnetic Resonance, 2010
- Pericardial Fat Is Independently Associated With Human Atrial FibrillationJournal of the American College of Cardiology, 2010
- Epicardial and Pericardial Fat: Close, but Very DifferentObesity, 2009
- Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volumeJournal of Cardiovascular Magnetic Resonance, 2009
- Cardiac Remodeling in ObesityPhysiological Reviews, 2008
- Human epicardial adipose tissue: A reviewAmerican Heart Journal, 2007
- Volumetric Assessment of Epicardial Adipose Tissue With Cardiovascular Magnetic Resonance ImagingObesity, 2007