Dermatofibrosarcoma protuberans with fibrosarcomatous areas. A clinicopathologic study of nine cases and a comparison with allied tumors
- 1 August 1989
Abstract
Nine cases of dermatofibrosarcoma protuberans with fibrosarcomatous areas (DFSP with FS) were analyzed clinicopathologically, and the findings compared with allied tumors comprising 43 cases of ordinary DFSP, ten of superficial fibrosarcoma (SFS), and 11 of storiform variant of malignant fibrous histiocytoma (SV MFH). All but one case of DFSP with FS developed on the trunk of the body. Eight of the nine patients (89%) had one recurrence with a shorter prerecurrent interval than that of the ordinary DFSP, and a hipbone metastasis was identified in one patient. These findings reflect the unfavorable course, in contrast to the ordinary DFSP. Microscopically, the FS areas were presented either in the initial lesion (five cases) or in the recurrent one (four cases), areas showing cellularity, mitotic figures, and cytologic anaplasia that exceeded those in the DFSP areas. Dermatofibrosarcoma protuberans with FS and allied categories such as SFS and SV MFH shared various clinical and histologic features but there was a diversity in the prognosis relative to the grade of malignancy. The relationship between DFSP with FS and the allied tumors was given attention.Keywords
This publication has 11 references indexed in Scilit:
- Fibrosarcomatous Change in Dermatofibrosarcoma ProtuberansThe American Journal of Surgical Pathology, 1988
- Progression of dermatofibrosarcoma protuberans to malignant fibrous histiocytoma:Report of a case with implications for tumor histogenesisHuman Pathology, 1988
- Malignant Fibrous Histiocytoma Tumor Cells Resemble FibroblastsThe American Journal of Surgical Pathology, 1986
- Dermatofibrosarcoma protuberans: a clinicopathological and immunohistochemical study with a review of the literatureHistopathology, 1985
- The fibroblastic nature of dermatofibrosarcoma protuberansVirchows Archiv, 1981
- Fibrosarcoma—a clinicopathologic and statistical study of 199 tumors of the soft tissues of the extremities and trunkCancer, 1974
- Dermatofibrosarcoma protuberans mit Übergang in ein sogenanntes FibrosarkomDermatology, 1974
- Dermatofibrosarcoma ProtuberansAnnals of Surgery, 1967
- Dermatofibrosarcoma protuberans: Study of fifty-six casesThe American Journal of Surgery, 1966
- Dermatofibrosarcoma protuberans.A study of 115 casesCancer, 1962