Childhood Linear IgA Bullous Disease Triggered by Amoxicillin‐Clavulanic Acid
- 6 August 2007
- journal article
- case report
- Published by Wiley in Pediatric Dermatology
- Vol. 24 (5), E40-E43
- https://doi.org/10.1111/j.1525-1470.2007.00438.x
Abstract
Linear immunoglobulin A bullous disease is an autoimmune subepidermal blistering disease that has been described in both children and adults. Reports have shown that as many as two-thirds of occurrences may be drug-induced. The offending drugs include antibiotics, predominantly vancomycin, nonsteroidal anti-inflammatory agents and diuretics. We report childhood linear immunoglobulin A bullous dermatosis developing following amoxicillin-clavulanic acid administration. The patient presented with characteristic blisters in an annular fashion, likened to a ''crown of jewels.'' The diagnosis was confirmed by the presence of a linear band of immunoglobulin A at the dermoepidermal junction on direct immunofluorescence. The lesions resolved with withdrawal of the drug, and systemic therapy was not required. We review the current literature and concepts of drug-induced linear immunoglobulin A bullous disease.Keywords
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