Acid aspiration prophylaxis in elective biliary surgery A comparison of omeprazole and famotidine using manually aided gastric aspiration
- 1 October 1994
- journal article
- clinical trial
- Published by Wiley in Anaesthesia
- Vol. 49 (10), 909-911
- https://doi.org/10.1111/j.1365-2044.1994.tb04274.x
Abstract
We have compared the effects of single oral doses of omeprazole 40 mg, famotidine 40 mg or placebo on gastric secretion in 45 non-obese patients the night before elective biliary surgery. After stable anaesthesia had been established, a Salem orogastric tube was introduced and gastric contents were aspirated by a blinded observer. The volume and pH were noted. After the abdomen was opened aspiration was repeated but on this occasion with the surgeon's manual assistance. We found that the initial aspirate volume underestimated total gastric volume by an average (SD) of 7.1 (6.6) ml. Famotidine, but not omeprazole, produced a significant decrease in gastric volume and acidity. Patients were considered to be at risk if pH < 2.5 and volume > 0.4 ml.kg-1. Three patients in the omeprazole group, three in the placebo group and none in the famotidine group came into this category. We conclude that a single oral dose of omeprazole 40 mg given the night before surgery does not afford adequate prophylaxis for acid aspiration syndrome.Keywords
This publication has 24 references indexed in Scilit:
- Prophylaxis against acid aspiration syndromeAnaesthesia, 2007
- EFFECTS OF OMEPRAZOLE, RANITIDINE, FAMOTIDINE AND LACEBO ON GASTRIC SECRETION IN PATIENTS NDERGOING ELECTIVE SURGERYBritish Journal of Anaesthesia, 1992
- Acid aspiration prophylaxis in morbidly obese patients: famotidine vs. ranitidineAnaesthesia, 1991
- OmeprazoleNew England Journal of Medicine, 1991
- CRITICAL VOLUME FOR PULMONARY ACID ASPIRATION: REAPPRAISAL IN A PRIMATE MODELBritish Journal of Anaesthesia, 1990
- Omeprazole for prophylaxis of acid aspiration in elective surgeryAnaesthesia, 1990
- Acid suppression in duodenal ulcer: a meta-analysis to define optimal dosing with antisecretory drugs.Gut, 1987
- Aspiration during anaesthesia: a computer‐aided study of 185 358 anaestheticsActa Anaesthesiologica Scandinavica, 1986
- Reducing the Risk of Acid Aspiration During Cesarean SectionAnesthesia & Analgesia, 1974
- The Aspiration of Stomach Contents into the Lungs During Obstetric AnesthesiaAmerican Journal of Obstetrics and Gynecology, 1946