Monitoring thermal-induced changes in tumor blood flow and microvessels with laser speckle contrast imaging
- 13 March 2007
- journal article
- Published by Optica Publishing Group in Applied Optics
- Vol. 46 (10), 1911-1917
- https://doi.org/10.1364/ao.46.001911
Abstract
Laser speckle contrast imaging (LSCI) was used to monitor thermal-induced changes in the blood flow and the diameter of mesenteric microvessels of normal and tumor bearing mice under treatment at different constant temperatures between . The results show that the blood flow and the diameter increase at the beginning and then reach a plateau and finally start to decrease. The lower the temperature, the longer the plateau stays. A t-test indicates that there is no significant difference in plateau values of relative blood flow and relative diameter for the same group. For normal mice, the relative increases in the blood flow and the diameter are 1.26 and 1.41, respectively, while for tumor-bearing mice they are 1.08 and 1.13, respectively. At higher treatment temperature or under longer heat treatment, there are decreases in the blood flow and the diameter, such changes in tumor-bearing mice are more obvious than those in normal mice, which means tumor microvessels are more sensitive to heat than normal. Moreover, thermal induced shrink of microvessel usually occurs sooner than the decrease in blood flow, and the relative change in diameter is larger than that in blood flow. Therefore we may conclude that deformation of vessel is a main factor for changing the blood perfusion of a microvessel.
Keywords
This publication has 22 references indexed in Scilit:
- On estimation of the temperature maximum in intraluminal or intracavitary hyperthermiaInternational Journal of Hyperthermia, 2005
- Measurement of depth of burns by laser Doppler perfusion imagingBurns, 2001
- Effect of nitric oxide synthase inhibition on regional blood flow during hyperthermiaJournal of Thermal Biology, 2001
- Hyperthermia in oncologyInternational Journal of Hyperthermia, 2001
- Measuring tumor blood flow with H215O: practical considerationsNuclear Medicine and Biology, 2000
- Boundary information based diagnostics on the thermal states of biological bodiesInternational Journal of Heat and Mass Transfer, 2000
- Changes in Local Hepatic Blood Perfusion During Interstitial Laser-Induced Thermotherapy of Normal Rat Liver Measured by Interstitial Laser Doppler FlowmetryLasers in Medical Science, 1999
- Estimation of blood perfusion using phase shift in temperature response to sinusoidal heating at the skin surfaceIEEE Transactions on Biomedical Engineering, 1999
- Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissueIEEE Journal of Selected Topics in Quantum Electronics, 1996
- Vascular thermal adaptation in tumors and normal tissue in ratsInternational Journal of Radiation Oncology*Biology*Physics, 1996