Differential Activation of Influenza A Virus Endonuclease Activity Is Dependent on Multiple Sequence Differences between the Virion RNA and cRNA Promoters
Open Access
- 15 February 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (4), 2019-2023
- https://doi.org/10.1128/jvi.76.4.2019-2023.2002
Abstract
Influenza virus endonuclease activity was studied in vitro with model virion RNA (vRNA) and cRNA molecules. We show that endonuclease activity can be partially rescued by transplanting vRNA-like promoter features into the model cRNA promoter. This study defines three distinctive features within the vRNA promoter—absent in the cRNA promoter—that are required for endonuclease cleavage.Keywords
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