Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates
- 6 August 2010
- journal article
- review article
- Published by SAGE Publications in Lupus
- Vol. 19 (9), 1050-1070
- https://doi.org/10.1177/0961203310370048
Abstract
The skin is the second most frequently affected organ system in lupus erythematosus. Although only very rarely life threatening — an example is lupus erythematosus-associated toxic epidermal necrolysis — skin disease contributes disproportionally to disease burden in terms of personal and psychosocial wellbeing, vocational disability, and hence in medical and social costs. Since several manifestations are closely associated with the presence and activity of systemic lupus erythematosus, prompt and accurate diagnosis of cutaneous lupus erythematosus is essential. This review aims to cover common, rare, and atypical manifestations of lupus erythematosus-associated skin disease with a detailed discussion of histopathological correlates. Cutaneous lupus erythematosus covers a wide morphological spectrum well beyond acute, subacute and chronic cutaneous lupus erythematosus, which are commonly classified as lupus-specific skin disease. Other uncommon or less well-known manifestations include lupus erythematosus tumidus, lupus profundus, chilblain lupus, mucosal lupus erythematosus, and bullous lupus erythematosus. Vascular manifestations include leukocytoclastic and urticarial vasculitis, livedoid vasculopathy and livedo reticularis/ racemosa. Finally, we discuss rare presentations such as lupus erythematosus-related erythema exsudativum multiforme (Rowell syndrome), Kikuchi-Fujimoto disease, extravascular necrotizing palisaded granulomatous dermatitis (Winkelmann granuloma), and neutrophilic urticarial dermatosis. Lupus (2010) 19, 1050—1070.Keywords
This publication has 99 references indexed in Scilit:
- Rheumatic manifestations of skin diseaseCurrent Opinion in Rheumatology, 2010
- Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factorsArthritis & Rheumatism, 2009
- UVB and Proinflammatory Cytokines Synergistically Activate TNF-α Production in Keratinocytes through Enhanced Gene TranscriptionJournal of Investigative Dermatology, 2009
- Cross-sectional Analysis of a Collaborative Web-Based Database for Lupus Erythematosus–Associated Skin LesionsArchives of Dermatology, 2009
- Trex1 Prevents Cell-Intrinsic Initiation of AutoimmunityCell, 2008
- Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosusNature Genetics, 2007
- Cutaneous lupus erythematosus simulating squamous neoplasia: The clinicopathologic conundrum and histopathologic pitfallsJournal of the American Academy of Dermatology, 2007
- A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupusJournal of Molecular Medicine, 2007
- Clinical and immunologic studies in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skinJournal of the American Academy of Dermatology, 1993
- Subacute cutaneous lupus erythematosus presenting as erythrodermaJournal of the American Academy of Dermatology, 1988