S-Bridged Thioether and Structure-Diversified Angucyclinone Derivatives from the South China Sea-Derived Micromonospora echinospora SCSIO 04089
- 24 September 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 83 (10), 3122-3130
- https://doi.org/10.1021/acs.jnatprod.0c00719
Abstract
Angucyclinces belong to the class of aromatic polyketides and display a wide variety of structure diversity and pharmaceutical significance. Herein we report the isolation, structure elucidation, and bioactivity evaluation of structure-diversified angucyclinone derivatives and anthracene from the South China Sea-derived Micromonospora echinospora SCSIO 04089, including a thioether, gephysulfuromycin (1), two new benzo[b]phenanthridines, homophenanthroviridone (2) and homophenanthridonamide (3), a new benzo[b]fluorene, homostealthin D (4), a new naphtho[2,3-b]benzofuran, nenesfuran (5), a new naphthoquinone, WS-5995 D (6) and a new anthracene, nenesophanol (7), together with three known compounds (8–10). Their structures were elucidated by extensive spectroscopic analyses. The structures of 1–3 and 5–8 were confirmed by X-ray crystallographic analyses. Gephysulfuromycin (1) featured a rare single S-bridged 3,12a-epithiotetraphene skeleton. Homophenanthroviridone (2) was found to be cytotoxic to SF-268, MCF-7, and HepG2 cell lines with IC50 values of 5.4 ± 0.4, 6.8 ± 0.3, and 1.4 ± 0.1 μM, respectively. Compound 2 was also active against Gram-positive bacteria with MIC (minimal inhibition concentration) values ranging 2–4 μg mL–1.Keywords
Funding Information
- Government of Guangdong Province ([2020]032, GDME-2018C005)
- National Natural Science Foundation of China (31700042, 31820103003, 41676165)
- Chinese Academy of Sciences (QYZDJ-SSW-DQC004, XDA13020302)
- Southern Marine Science and Engineering Guangdong Laboratory (GML2019ZD0406)
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