Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus.
Open Access
- 1 October 1988
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 168 (4), 1475-1480
- https://doi.org/10.1084/jem.168.4.1475
Abstract
Serum from patients with systemic lupus erythematosus (SLE) frequently contain IgM and IgG autoantibodies to the constitutively expressed 73-kD/pI 5.5 member of the hsp70 family of heat shock proteins, as determined by one-dimensional (SDS-PAGE) and two-dimensional (IEF/SDS-PAGE) immunoblotting, and by solid-phase SLE Ig immunoprecipitation experiments using hsp70 protein-specific mAbs as probes. Autoantibodies to hsp70 also were detected in a minority of sera from patients with other rheumatic or viral diseases, but not in normal sera. These data may provide additional insight into etiologic and pathophysiologic mechanisms in this and related autoimmune disorders.Keywords
This publication has 13 references indexed in Scilit:
- Stress proteins are immune targets in leprosy and tuberculosis.Proceedings of the National Academy of Sciences, 1988
- Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus.JCI Insight, 1988
- A major immunogen in Schistosoma mansoni infections is homologous to the heat-shock protein Hsp70.The Journal of Experimental Medicine, 1987
- Autoantibodies in infectious mononucleosis have specificity for the glycine-alanine repeating region of the Epstein-Barr virus nuclear antigen.The Journal of Experimental Medicine, 1987
- Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.The Journal of cell biology, 1986
- Heat shock proteins: the search for functions.The Journal of cell biology, 1986
- Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoproteinCell, 1983
- The 1982 revised criteria for the classification of systemic lupus erythematosusArthritis & Rheumatism, 1982
- Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and MedicineAdvances in Immunology, 1982
- High resolution two-dimensional electrophoresis of proteins.1975