Pesticide/Environmental Exposures and Parkinson's Disease in East Texas
- 27 June 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Journal of Agromedicine
- Vol. 13 (1), 37-48
- https://doi.org/10.1080/10599240801986215
Abstract
Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population.Keywords
This publication has 59 references indexed in Scilit:
- No evidence for heritability of Parkinson disease in Swedish twinsNeurology, 2004
- Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein AggregationExperimental Neurology, 2003
- The genetic basis of Parkinson's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2002
- Parkinson Disease in TwinsAn Etiologic StudyJAMA, 1999
- Environmental risk factors and Parkinson's diseaseNeurology, 1997
- Possible environmental, occupational, and other etiologic factors for Parkinson's diseaseNeurology, 1996
- A case‐control study of Parkinson's disease in a horticultural region of British ColumbiaMovement Disorders, 1994
- Risk factors for Parkinson's diseaseNeurology, 1993
- Parkinson's disease and exposure to agricultural work and pesticide chemicalsNeurology, 1992
- Clustering of Parkinson's Disease Points to Environmental EtiologyArchives of environmental health, 1990