Palladium-Catalyzed Transformations of Alkyl C–H Bonds
Top Cited Papers
- 2 December 2016
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 117 (13), 8754-8786
- https://doi.org/10.1021/acs.chemrev.6b00622
Abstract
This Review summarizes the advancements in Pd-catalyzed C(sp3)–H activation via various redox manifolds, including Pd(0)/Pd(II), Pd(II)/Pd(IV), and Pd(II)/Pd(0). While few examples have been reported in the activation of alkane C–H bonds, many C(sp3)–H activation/C–C and C–heteroatom bond forming reactions have been developed by the use of directing group strategies to control regioselectivity and build structural patterns for synthetic chemistry. A number of mono- and bidentate ligands have also proven to be effective for accelerating C(sp3)–H activation directed by weakly coordinating auxiliaries, which provides great opportunities to control reactivity and selectivity (including enantioselectivity) in Pd-catalyzed C–H functionalization reactions.Keywords
Funding Information
- National Science Foundation (CHE-1465292)
- Agency for Science, Technology and Research
- Bristol-Myers Squibb
- Center for Selective C-H Functionalization, National Science Foundation (CHE-0943980)
- U.S. Department of Health and Human Services (2R01GM084019)
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