Ubiquitin-binding domains
Top Cited Papers
- 1 August 2005
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 6 (8), 610-621
- https://doi.org/10.1038/nrm1701
Abstract
Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-covalently bind to ubiquitin. These recently discovered motifs interpret and transmit information conferred by protein ubiquitylation to control various cellular events. Detailed molecular structures are known for a number of UBDs, but to understand their mechanism of action, we also need to know how binding specificity is determined, how ubiquitin binding is regulated, and the function of UBDs in the context of full-length proteins. Such knowledge will be key to our understanding of how ubiquitin regulates cellular proteins and processes.Keywords
This publication has 99 references indexed in Scilit:
- Evolving nature of the AP2 α-appendage hub during clathrin-coated vesicle endocytosisThe EMBO Journal, 2004
- GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi networkNature, 2004
- Tom1, a VHS Domain-containing Protein, Interacts with Tollip, Ubiquitin, and ClathrinJournal of Biological Chemistry, 2003
- A proteomics approach to understanding protein ubiquitinationNature Biotechnology, 2003
- Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosolThe Journal of cell biology, 2003
- A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domainThe EMBO Journal, 2003
- Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8Nature, 2003
- A Ubiquitin-interacting Motif (UIM) Is Essential for Eps15 and Eps15R UbiquitinationOnline Journal of Public Health Informatics, 2002
- Solution Structures of UBA Domains Reveal a Conserved Hydrophobic Surface for Protein–Protein InteractionsJournal of Molecular Biology, 2002
- Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solutionJournal of Molecular Biology, 1999