Molecular Complexity via C–H Activation: A Dehydrogenative Diels–Alder Reaction
- 15 August 2011
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 133 (38), 14892-14895
- https://doi.org/10.1021/ja2059704
Abstract
Traditionally, C–H oxidation reactions install oxidized functionality onto a preformed molecular skeleton, resulting in a local molecular change. The use of C–H activation chemistry to construct complex molecular scaffolds is a new area with tremendous potential in synthesis. We report a Pd(II)/bis-sulfoxide-catalyzed dehydrogenative Diels–Alder reaction that converts simple terminal olefins into complex cycloadducts in a single operation.Keywords
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