Antibiotic prophylaxis in intraoral orthognathic surgery
- 1 December 1984
- journal article
- case report
- Published by Elsevier BV in Journal of Oral and Maxillofacial Surgery
- Vol. 42 (12), 797-801
- https://doi.org/10.1016/0278-2391(84)90348-3
Abstract
A prospective randomized double-blind study was conducted to evaluate two prophylactic antibiotic regimens in a population of 40 patients undergoing intraoral orthognathic surgery. All patients received one intramuscular dose of 600,000 units procaine penicillin G and 400,000 units aqueous penicillin G preoperatively. Two million units aqueous penicillin G were administered intravenously every three hours intraoperatively and postoperatively three hours after the last intraoperative dose. One group of 20 patients then received 2 million units aqueous penicillin G intravenously every four hours for a total of 12 doses (two days) postoperatively. The second group of 20 patients received a placebo intravenously every four hours for a total of 12 doses (two days) postoperatively. Three infections occurred in the group of patients receiving the placebo postoperatively and none in the group of patients receiving the antibiotics postoperatively.Keywords
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