The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody‐like V genes
Open Access
- 29 July 2010
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 40 (8), 2319-2329
- https://doi.org/10.1002/eji.201040515
Abstract
The content and organization of the Xenopus tropicalis TCRα/δ locus was determined. This locus is highly conserved among tetrapods, with the genes encoding the TCRδ chains embedded with those encoding TCRα. However, the frog TCRα/δ is unusual in that it contains V genes that appear indistinguishable from those in the IgH locus (VH). These V genes, termed VHδ, make up 70% of the V genes at the TCRδ locus and are expressed exclusively in TCRδ chains. Finding TCRδ chains that use antibody‐like V domains in frogs is similar to the situation in shark TCRδ variants and TCRμ in marsupials. These results suggest that such unconventional TCR may be more widespread across vertebrate lineages than originally thought and raise the possibility of previously unrealized subsets of T cells. We also revealed close linkage of TCRα/δ, IgH, and Igλ in Xenopus which, in combination with linkage analyses in other species, is consistent with the previous models for the emergence of these antigen receptor loci.Keywords
This publication has 50 references indexed in Scilit:
- γδ T Cells and the Lymphoid Stress-Surveillance ResponseImmunity, 2009
- Characterization of arrangement and expression of the T cell receptor γ locus in the sandbar sharkProceedings of the National Academy of Sciences of the United States of America, 2009
- Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domesticaBMC Genomics, 2008
- A unique T cell receptor discovered in marsupialsProceedings of the National Academy of Sciences of the United States of America, 2007
- Identification of IgF, a hinge-region-containing Ig class, and IgD inXenopus tropicalisProceedings of the National Academy of Sciences of the United States of America, 2006
- IgD, like IgM, is a primordial immunoglobulin class perpetuated in most jawed vertebratesProceedings of the National Academy of Sciences of the United States of America, 2006
- Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co‐evolution among MHC class I region genesEuropean Journal of Immunology, 2003
- The Old and the RestlessThe Journal of Experimental Medicine, 2000
- Development of the early B cell population inXenopusEuropean Journal of Immunology, 1998
- The T Cell Receptor/CD3 Complex: A Dynamic Protein EnsembleAnnual Review of Immunology, 1988