Integrated testing and intelligent assessment—new challenges under REACH
- 26 September 2008
- journal article
- Published by Springer Science and Business Media LLC in Environmental Science and Pollution Research
- Vol. 15 (7), 565-572
- https://doi.org/10.1007/s11356-008-0043-y
Abstract
Due to a number of drawbacks associated with the previous regime for the assessment of new and existing chemicals, the European Union established a new regulation concerning the registration, evaluation, authorisation and restriction of chemicals (REACH). All relevant industrial chemicals must now be assessed. Instead of the authorities, industry itself is responsible for the risk assessment. To achieve better and more efficient assessments while reducing animal testing, all information—standard, non-standard and non-testing—has to be used in an integrated manner. To meet these challenges, the current technical guidance documents for risk assessment of new and existing chemicals had to be updated and extended considerably. This was done by experts in a number of REACH Implementation Projects. This paper presents the most relevant results of the expert Endpoint Working Group on Aquatic Toxicity in order to illustrate the change of paradigm in the future assessment of hazards to the aquatic environment by chemical substances.Keywords
This publication has 10 references indexed in Scilit:
- Acute to chronic ratios in aquatic toxicity—variation across trophic levels and relationship with chemical structureEnvironmental Toxicology and Chemistry, 2006
- SAR and QSAR modeling of endocrine disruptorsSAR and QSAR in Environmental Research, 2006
- Nature of the Binding Interaction for 50 Structurally Diverse Chemicals with Rat Estrogen ReceptorsToxicological Sciences, 2006
- Prediction of estrogenicity: validation of a classification modelSAR and QSAR in Environmental Research, 2006
- Ten challenges for improved ecotoxicological testing in environmental risk assessmentEcotoxicology and Environmental Safety, 2006
- A strategy to reduce the use of fish in acute ecotoxicity testing of new chemical substances notified in the European UnionRegulatory Toxicology and Pharmacology, 2005
- Structural AlertsA New Classification Model to Discriminate Excess Toxicity from Narcotic Effect Levels of Organic Compounds in the Acute Daphnid AssayChemical Research in Toxicology, 2005
- Evaluation of EU risk assessments existing chemicals (EC Regulation 793/93)Chemosphere, 2003
- Regulatory application of SAR/QSAR for priority setting of endocrine disruptors: A perspectivePure and Applied Chemistry, 2003
- Classifying environmental pollutantsChemosphere, 1992