Agonist‐selective signaling of G protein‐coupled receptor: Mechanisms and implications
Open Access
- 7 January 2010
- journal article
- review article
- Published by Wiley in IUBMB Life
- Vol. 62 (2), 112-119
- https://doi.org/10.1002/iub.293
Abstract
Agonist‐selective signaling or ligand‐biased signaling of G protein‐coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The principle of this concept is that agonist possesses different abilities to activate different signaling pathways. Current review summarizes the observations of agonist‐selective signaling of various GPCRs, indicating the significance of agonist‐selective signaling in biological processes. In addition, current review also provides an overview on how agonist‐selective signaling is initiated. Especially, the relationship between GPCR‐G protein interaction and GPCR‐β‐arrestin interaction is discussed in depth. © 2010 IUBMB IUBMB Life, 62(2): 112–119, 2010Keywords
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