Analysis of the intraductal microenvironment for the early diagnosis of breast cancer: identification of biomarkers in nipple-aspirate fluids
- 31 October 2008
- journal article
- Published by Informa Healthcare in Expert Opinion on Medical Diagnostics
- Vol. 2 (11), 1221-1231
- https://doi.org/10.1517/17530059.2.11.1221
Abstract
Breast cancer, a complex and multifactorial disease, is the most commonly diagnosed malignancy that affects women. Methods of breast cancer detection that are available at present have well-described limitations; the intraductal approaches directly assess the microenvironment of the breast. The aim of this overview is to highlight the application of nipple-aspirate fluid studies in the field of biomarker discovery, useful for early detection and prevention of breast cancer risk. Nipple-aspirate fluids can be obtained non-invasively from the breast in most women and represent a promising biological tool to assess metabolic and molecular changes of cells lining the ducts from which breast cancer arises.Keywords
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