Risks and benefits of weight loss: challenges to obesity research
Open Access
- 1 November 2005
- journal article
- Published by Oxford University Press (OUP) in European Heart Journal Supplements
- Vol. 7 (suppl_L), L27-L31
- https://doi.org/10.1093/eurheartj/sui083
Abstract
It is well accepted that being overweight or obese carries risks to health, but there is less agreement as to whether weight loss produces benefits on mortality and on cardiovascular event rates. The evidence from observational studies is conflicting: some studies have shown weight loss to be associated with increased mortality, but this could be because differentiation was not made between intentional and unintentional weight loss. Mechanistic hypotheses can be raised for both beneficial and harmful effects of weight loss. Randomized controlled clinical trials are needed to establish the effect of intentional weight loss and two large outcome studies are now under way: SCOUT and Look AHEAD. These trials are assessing the effect of weight loss on cardiovascular endpoints. Such trials are complex and expensive to undertake, but are important if we are to establish whether weight loss is truly associated with a reduction in mortality.Keywords
This publication has 12 references indexed in Scilit:
- What is the relationship between risk factor reduction and degree of weight loss?European Heart Journal Supplements, 2005
- The SCOUT study: risk-benefit profile of sibutramine in overweight high-risk cardiovascular patientsEuropean Heart Journal Supplements, 2005
- Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric SurgeryThe New England Journal of Medicine, 2004
- Obesity and heart failure prognosis: paradox or reverse epidemiology?European Heart Journal, 2004
- Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetesControlled Clinical Trials, 2003
- Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational studyThe Lancet, 2003
- Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminThe New England Journal of Medicine, 2002
- Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose ToleranceThe New England Journal of Medicine, 2001
- Benefits and Adverse Effects of Weight Loss: Observations from the Framingham StudyAnnals of Internal Medicine, 1993
- Diagnosis and Prevalence of ObesityMedical Clinics of North America, 1989