Perfusion imaging with a freely diffusible hyperpolarized contrast agent
Open Access
- 22 March 2011
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 66 (3), 746-755
- https://doi.org/10.1002/mrm.22860
Abstract
Contrast agents that can diffuse freely into or within tissue have numerous attractive features for perfusion imaging. Here we present preliminary data illustrating the suitability of hyperpolarized 13C labeled 2‐methylpropan‐2‐ol (also known as dimethylethanol, tertiary butyl alcohol and tert‐butanol) as a freely diffusible contrast agent for magnetic resonance perfusion imaging. Dynamic 13C images acquired in rat brain with a balanced steady‐state free precession sequence following administration of hyperpolarized 2‐methylpropan‐2‐ol show that this agent can be imaged with 2–4s temporal resolution, 2 mm slice thickness, and 700 μm in‐plane resolution while retaining adequate signal‐to‐noise ratio. 13C relaxation measurements on 2‐methylpropan‐2‐ol in blood at 9.4T yield T 1 = 46 ± 4s and T 2 = 0.55 ± 0.03s. In the rat brain at 4.7T, analysis of the temporal dynamics of the balanced steady‐state free precession image intensity in tissue and venous blood indicate that 2‐methylpropan‐2‐ol has a T 2 of roughly 2–4s and a T 1 of 43 ± 24s. In addition, the images indicate that 2‐methylpropan‐2‐ol is freely diffusible in brain and hence has a long residence time in tissue; this in turn makes it possible to image the agent continuously for tens of seconds. These characteristics show that 2‐methylpropan‐2‐ol is a promising agent for robust and quantitative perfusion imaging in the brain and body. Magn Reson Med, 2011.Keywords
Funding Information
- National Institutes of Health (R21 EB8159, R03 EB8721)
This publication has 41 references indexed in Scilit:
- In vivo hadamard encoded continuous arterial spin labeling (H-CASL)Magnetic Resonance in Medicine, 2010
- Investigation of tumor hyperpolarized [1-
13
C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSIMagnetic Resonance in Medicine, 2010
- Dynamic Nuclear Polarization with Trityls at 1.2 KApplied Magnetic Resonance, 2008
- Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniquesThe British Journal of Radiology, 2006
- Methyltertiary-Butyl Ether: Studies for Potential Human Health HazardsCritical Reviews in Toxicology, 2006
- Cerebral perfusion assessment by bolus tracking using hyperpolarized 13CMagnetic Resonance in Medicine, 2004
- Hyperpolarized 13C MR angiography using trueFISPMagnetic Resonance in Medicine, 2003
- On the transient phase of balanced SSFP sequencesMagnetic Resonance in Medicine, 2003
- The sensitivity of low flip angle RARE imagingMagnetic Resonance in Medicine, 1997
- High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part II: Experimental comparison and preliminary resultsMagnetic Resonance in Medicine, 1996