Neoplasms in rats and mice fed butylurea and sodium nitrite separately and in combination
- 15 February 1979
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 23 (2), 253-259
- https://doi.org/10.1002/ijc.2910230217
Abstract
In projected 485‐day studies, Fischer 344 rats and C57BL/6 mice were fed 0.58% butylurea and 0.50% sodium nitrite mixed in the diet separately or in combination. The number and type of neoplasms were not significantly increased in either species receiving butylurea or sodium nitrite only. Feeding the two chemicals simultaneously induced neoplasms of the lung, Zymbal's gland, forestomach, intestine and hemopoietic tissues in rats, and malignant lymphomas in mice. The increased incidence of neoplasms in rats and mice fed butylurea and sodium nitrite in combination may result from in vivo formation of the carcinogen, N‐butyl‐N‐nitrosourea.This publication has 13 references indexed in Scilit:
- Induction of Mouse Lung Adenomas by Amines or Ureas Plus Nitrite and by N-Nitroso Compounds: Effect of Ascorbate, Gallic Acid, Thiocyanate, and Caffeine2JNCI Journal of the National Cancer Institute, 1975
- Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl- and ethylnitrosourea precursors to adult ratsFood and Cosmetics Toxicology, 1975
- Induction of liver and lung tumours in rats by the simultaneous administration of sodium nitrite and morpholineFood and Cosmetics Toxicology, 1973
- The formation of carcinogenic nitroso compounds from nitrite and some types of agricultural chemicalsFood and Cosmetics Toxicology, 1973
- Malignant Tumours of Liver and Lung in Rats fed Aminopyrine or Heptamethyleneimine together with NitriteNature, 1973
- Carcinogen Dimethylnitrosamine produced in vivo from Nitrite and AminopyrineNature New Biology, 1972
- Evidence of formation of N‐methyl‐N‐nitrosourea in rats given n‐methylurea and sodium nitriteInternational Journal of Cancer, 1971
- Weitere Versuche zur Tumor-Induktion durch orale Applikation niederer Dosen von N-Methylbenzylamin und NatriumnitritZeitschrift für Krebsforschung und Klinische Onkologie, 1971
- Nitrosamines as Environmental CarcinogensNature, 1970
- Effectiveness of Ice containing Sodium Nitrite for Fish PreservationJournal of the Fisheries Research Board of Canada, 1940