Polydisulfide-based Biodegradable Macromolecular Magnetic Resonance Imaging Contrast Agents
- 27 August 2010
- journal article
- review article
- Published by Wiley in Israel Journal of Chemistry
- Vol. 50 (2), 220-232
- https://doi.org/10.1002/ijch.201000016
Abstract
Macromolecular Gd(III) complexes are advantageous over small molecular Gd(III) complexes in contrast‐enhanced magnetic resonance imaging (MRI) because of their prolonged blood circulation and preferential tumor accumulation. However, macromolecular contrast agents have not been approved for clinical applications because of the safety concerns related to their slow body excretion. Polydisulfide Gd(III) complexes have been designed and developed as biodegradable macromolecular MRI contrast agents to alleviate these concerns by facilitating the clearance of Gd(III) complexes from the body. These agents initially behave as macromolecular agents and result in superior contrast enhancement in the vasculature and tumor tissues. They can then be readily degraded in vivo into small molecular chelates that can be rapidly excretede from the body via renal filtration after the MRI examinations. Various polydisulfide Gd(III) complexes have been prepared as biodegradable macromolecular MRI contrast agents. These agents have resulted in strong contrast enhancement in the vasculature and tumor tissue in animal models with minimal long‐term tissue accumulation when compared to small molecular contrast agents. Polydisulfide Gd(III) complexes are promising for further clinical development as safe and effective biodegradable macromolecular MRI contrast agents for cardiovascular and cancer imaging. The review summarizes the chemistry and properties of polydisulfide Gd(III) complexes.Keywords
This publication has 44 references indexed in Scilit:
- Noninvasive Evaluation of Antiangiogenic Effect in a Mouse Tumor Model by DCE-MRI with Gd-DTPA Cystamine CopolymersMolecular Pharmaceutics, 2009
- Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapyJournal of Magnetic Resonance Imaging, 2009
- Tumor Characterization with Dynamic Contrast Enhanced Magnetic Resonance Imaging and Biodegradable Macromolecular Contrast Agents in MicePharmaceutical Research, 2009
- Structural effect on degradability and in vivo contrast enhancement of polydisulfide Gd(III) complexes as biodegradable macromolecular MRI contrast agentsMagnetic Resonance Imaging, 2009
- Synthesis and Evaluation of Globular Gd-DOTA-Monoamide Conjugates with Precisely Controlled Nanosizes for Magnetic Resonance AngiographyBiomacromolecules, 2008
- Modification of Gd‐DTPA cystine copolymers with PEG‐1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiographyMagnetic Resonance in Medicine, 2007
- Nano-sized MRI contrast agents with dendrimer coresAdvanced Drug Delivery Reviews, 2005
- Contrast‐enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor‐bearing miceMagnetic Resonance in Medicine, 2005
- Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancerJournal of Magnetic Resonance Imaging, 2003
- Macromolecular MRI Contrast Agents with Small Dendrimers: Pharmacokinetic Differences between Sizes and CoresBioconjugate Chemistry, 2003