Acute and Long-term Complications of Corticosteroid Pulse Therapy
- 1 January 1984
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Journal of Rheumatology
- Vol. 13 (sup54), 27-32
- https://doi.org/10.3109/03009748409103858
Abstract
Complications caused by pulse therapy (PT) using “suprapharmacological” doses of methylprednisolone (MP) are reviewed. The reported adverse effects vary between 0 and 56% in different series. More intense and prolonged PT seems to result in higher toxicity. An improvement in therapeutic index for PT over oral corticosteroids has been found in two out of three controlled studies on renal transplant rejection. No controlled studies of PT in SLE have been published. Neuropsychiatric reactions occur in both SLE and RA.Keywords
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