Vitamin C Intake, Circulating Vitamin C and Risk of Stroke: A Meta‐Analysis of Prospective Studies
Open Access
- 18 November 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Heart Association
- Vol. 2 (6), e000329
- https://doi.org/10.1161/jaha.113.000329
Abstract
Background: Though vitamin C supplementation has shown no observed effects on stroke prevention in several clinical trials, uncertainty remains as to whether long‐term, low‐dose intake influences the development of stroke among general populations. Furthermore, the association between circulating vitamin C and the risk of stroke is also unclear. For further clarification of these issues, we conducted a meta‐analysis of prospective studies. Methods and Results: PubMed and EMBASE databases were searched, and the bibliographies of the retrieved articles were also reviewed to identify eligible studies. Summary relative risk ( RR s) with corresponding 95% confidence intervals ( CI s) were computed with a random‐effects model. The summary RR for the high‐versus‐low categories was 0.81 (95% CI : 0.74 to 0.90) for dietary vitamin C intake (11 studies), and 0.62 (95% CI : 0.49 to 0.79) for circulating vitamin C (6 studies). The summary RR for each 100 mg/day increment in dietary vitamin C was 0.83 (95% CI : 0.75 to 0.93) (10 studies), and for each 20 μmol/L increment in circulating vitamin C was 0.81 (95% CI : 0.75 to 0.88) (5 studies). Few studies reported results for vitamin C supplements ( RR for high‐versus‐low intake=0.83, 95% CI : 0.62 to 1.10, 3 studies). Conclusions: This meta‐analysis suggests significant inverse relationships between dietary vitamin C intake, circulating vitamin C, and risk of stroke.Keywords
This publication has 48 references indexed in Scilit:
- Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trialsThe American Journal of Clinical Nutrition, 2012
- Meta-Analysis for Linear and Nonlinear Dose-Response Relations: Examples, an Evaluation of Approximations, and SoftwareAmerican Journal of Epidemiology, 2011
- Clinical trials of antioxidants as cancer prevention agents: Past, present, and futureFree Radical Biology & Medicine, 2011
- Effects of vitamins C and E and β-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trialThe American Journal of Clinical Nutrition, 2009
- Total and Cancer Mortality After Supplementation With Vitamins and Minerals: Follow-up of the Linxian General Population Nutrition Intervention TrialJNCI Journal of the National Cancer Institute, 2009
- Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White womenNutrition Journal, 2008
- Vitamins E and C in the Prevention of Cardiovascular Disease in MenJama-Journal Of The American Medical Association, 2008
- A Randomized Factorial Trial of Vitamins C and E and Beta Carotene in the Secondary Prevention of Cardiovascular Events in WomenArchives of Internal Medicine, 2007
- Quantifying heterogeneity in a meta-analysisStatistics in Medicine, 2002
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986