Lack of Effect of Calcium Intake on the 25-Hydroxyvitamin D Response to Oral Vitamin D3
Open Access
- 1 February 2005
- journal article
- clinical trial
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 90 (2), 707-711
- https://doi.org/10.1210/jc.2004-1380
Abstract
This study was conducted to examine the effect of calcium intake on the rise in serum 25-hydroxyvitamin D [25(OH)D] levels in response to supplemental vitamin D3. Fifty-two healthy older men and women were randomly assigned to take calcium (500 mg twice daily with meals) or placebo tablets for 90 d between October 1 and the end of March. All participants were placed on 800 IU/d (20 μg/d) vitamin D3. Serum 25(OH)D measurements were made at baseline and on d 30, 60, and 90. The mean baseline 25(OH)D values were 19.2 ± 6.4 ng/ml (47.9 ± 15.9 nmol/liter) in the calcium group and 19.6 ± 6.7 ng/ml (49.1 ± 16.7 nmol/liter) in the control group (P = 0.808). The difference in pattern of change in 25(OH)D was not statistically significant (group by time interaction, P = 0.651); the calcium group increased 6.5 ± 5.9 ng/ml (16.2 ± 14.8 nmol/liter; P < 0.001), and the control group increased 6.6 ± 7.0 ng/ml (16.6 ± 17.4 nmol/liter; P < 0.001). The 95% confidence interval for difference in mean increase, calcium vs. control, was −3.8 ± 3.5 ng/ml (−9.6, 8.7) nmol/liter. In older men and women, the level of calcium intake, within the range of 500-1500 mg/d, does not have an important effect on the rise in serum 25(OH)D that occurs in response to 800 IU (20 μg)/d vitamin D3.Keywords
This publication has 20 references indexed in Scilit:
- Effect of calcium intake on serum levels of 25‐hydroxyvitamin D3European Journal of Clinical Investigation, 1988
- Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidismClinical Science, 1987
- Evidence that calcium modulates circulating 25-hydroxyvitamin D in manJournal of Bone and Mineral Research, 1987
- On the regulatory importance of 1,25-dihydroxyvitamin D3 and dietary calcium on serum levels of 25-hydroxyvitamin D3 in ratsBiochemical and Biophysical Research Communications, 1987
- A new mechanism for induced vitamin D deficiency in calcium deprivationNature, 1987
- Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.JCI Insight, 1986
- Substrate-Product Relation of 1-Hydroxylase Activity in Primary HyperparathyroidismNew England Journal of Medicine, 1985
- Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man.JCI Insight, 1984
- Effect of the administration of 1,25-dihydroxyvitamin D3 on serum levels of 25-hydroxyvitamin D in postmenopausal osteoporosisCalcified Tissue International, 1982
- MODULATION OF PLASMA 1,25-DIHYDROXYVITAMIN D IN MAN BY STIMULATION AND SUPPRESSION TESTSThe Lancet, 1979