Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal status
- 20 June 2005
- journal article
- research article
- Published by Wiley in Journal of Medical Primatology
- Vol. 34 (4), 171-177
- https://doi.org/10.1111/j.1600-0684.2005.00114.x
Abstract
Naturally occurring post-menopausal (PM) female cynomolgus monkeys (Macaca fascicularis) were identified. Their sex hormone profile was characterized and compared with younger pre-menopausal females before and after ovariectomy (OVX). PM females had lower estrogens and increased follicle-stimulating hormone (FSH) concentrations. Two PM females had diabetes mellitus and elevated androgens (androstenodione and dihydroepiandrosterone sulfate). Non-diabetic PM females were given parenteral E(2) which normalized FSH, and caused improvements in body weight, plasma lipids and lipoprotein cholesterol. Androgens remained lower with E(2) treatment. OVX induced comparable increases in FSH seen with the PM monkeys, however they had lower body weights, and had higher estrone and androstenodione concentrations. Natural menopause occurs in cynomolgus monkeys and hormone changes with OVX are similar however, differences in sex hormones that can relate to body mass and age may be important. E(2) treatment restored estrogen levels and induced improvements in the lipid profile of PM females.Keywords
This publication has 30 references indexed in Scilit:
- Effects of transdermal and oral estrogen replacement on lipids and glucose metabolism in postmenopausal women with type 2 diabetes mellitusClimacteric, 2002
- Adiposity, insulin and lipid metabolism in post-menopausal womenInternational Journal of Obesity, 2002
- Effects of transdermal and oral estrogen replacement on lipids and glucose metabolism in postmenopausal women with type 2 diabetes mellitusClimacteric, 2002
- Estradiol Increases IRS-1 Gene Expression and Insulin Signaling in Breast Cancer CellsBiochemical and Biophysical Research Communications, 2001
- Insulin Sensitivity and Cardiovascular Risk Factors in Ovariectomized Monkeys with Estradiol Alone or Combined with Nomegestrol AcetateJournal of Clinical Endocrinology & Metabolism, 1998
- Medroxyprogesterone Acetate Antagonizes Inhibitory Effects of Conjugated Equine Estrogens on Coronary Artery AtherosclerosisArteriosclerosis, Thrombosis, and Vascular Biology, 1997
- Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist- hip ratio, and noninsulin-dependent diabetes in postmenopausal women: the Rancho Bernardo StudyJournal of Clinical Endocrinology & Metabolism, 1996
- Reproductive Senescence in Female Japanese Monkeys (Macaca Fuscata): Age- and Season-Related Changes in Hypothalamic-Pituitary-Ovarian Functions And Fecundity RatesBiology of Reproduction, 1995
- Sex Steroid Influence on Hepatic Gluconeogenesis and Glycogen Formation1Endocrinology, 1973
- Cyclicity and gestation length ofMacaca fascicularisPrimates, 1972