Chemotherapy improves thymoma-associated graft-versus-host-disease-like erythroderma
- 10 May 2011
- journal article
- case report
- Published by BMJ in BMJ Case Reports
- Vol. 2011 (may08 1)
- https://doi.org/10.1136/bcr.03.2011.3936
Abstract
Graft-versus-host-disease (GVHD) with erythroderma can rarely occur in the context of thymoma and is associated with a poor prognosis due to an increased risk of infection-related death. The present study describes a case of a 50-year-old man with malignant thymoma who developed sepsis in addition to skin manifestations similar to that seen in GVHD. This patient experienced marked improvement in skin lesions in response to steroids and combination chemotherapy with carboplatin and paclitaxel, with subsequent resolution of infection. The present study describes the clinical course of this patient, followed by a review of pertinent reports of thymoma associated with GVHD with particular focus on the efficacy of treatment strategies.Keywords
This publication has 17 references indexed in Scilit:
- Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinomaLung Cancer, 2010
- Graft-versus-host disease-type colitis: an unusual association of malignant thymomaThe Annals of Thoracic Surgery, 2002
- CASE REPORT: Graft-Versus-Host-Like Colitis and Malignant ThymomaDigestive Diseases and Sciences, 2002
- Malignant thymoma: current status and future directionsCancer Treatment Reviews, 2000
- Graft-versus-Host Disease-like Syndrome in Malignant ThymomaScandinavian Journal of Gastroenterology, 2000
- Thymoma-associated cutaneous graft-versus-host-like reaction.1997
- Graft-Versus-Host–Like Colitis Associated with Malignant ThymomaThe American Journal of Surgical Pathology, 1995
- Graft-versus-Host DiseaseThe New England Journal of Medicine, 1991
- A retrospective analysis of therapy for acute graft-versus-host disease: initial treatment.1990
- Follow-up study of thymomas with special reference to their clinical stagesCancer, 1981