La Carcinine (β-alanyl-Histamine): Synthèse Rapide, Action Sur La Pression Sanguine Des Vertébrés

Abstract

1.—Synthesis of carcinine was performed by direct condensation of β-alanine with histamine (free base), in the presence of N-N′-dicyclocarbodiimide. The amine radical of β-alanine was protected by the t-butoxycarbonyl radical. This fast and simple method yielded a perfectly pure crystalline product. 2.—Carcinine had no influence upon heartbeat frequency nor on respiratory movements in rats. 3.—Carcinine had a vasodepressive action upon Vertebrates. It was active at half the concentration of carnosine and at about a thousand times the concentration of histamine. It appeared that histamine lost a great extent of its activity when linked with β-alanine.