Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan
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Open Access
- 21 July 2020
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Cellular and Infection Microbiology
- Vol. 10, 404
- https://doi.org/10.3389/fcimb.2020.00404
Abstract
Background: The ABO blood group system has been associated with multiple infectious diseases, including hepatitis B, dengue haemorrhagic fever and so on. Coronavirus disease 2019 (COVID-19) is a new respiratory infectious disease and the relationship between COVID-19 and ABO blood group system needs to be explored urgently. Methods: A hospital-based case-control study was conducted at Zhongnan Hospital of Wuhan University from 1 January 2020 to 5 March 2020. A total of 105 COVID-19 cases and 103 controls were included. The blood group frequency was tested with the chi-square statistic, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated between cases and controls. In addition, according to gender, the studied population was divided into two subgroups, and we assessed the association between cases and controls by gender. Finally, considering lymphopenia as a feature of COVID-19, the relationship between the ABO blood group and the lymphocyte count was determined in case samples. Results: The frequencies of blood types A, B, AB, and O were 42.8, 26.7, 8.57, and 21.9%, respectively, in the case group. Association analysis between the ABO blood group and COVID-19 indicated that there was a statistically significant difference for blood type A (P = 0.04, OR = 1.33, 95% CI = 1.02–1.73) but not for blood types B, AB or O (P = 0.48, OR = 0.90, 95% CI = 0.66–1.23; P = 0.61, OR = 0.88, 95% CI = 0.53–1.46; and P = 0.23, OR = 0.82, 95% CI = 0.58–1.15, respectively). An analysis stratified by gender revealed that the association was highly significant between blood type A in the female subgroup (P = 0.02, OR = 1.56, 95% CI = 1.08–2.27) but not in the male subgroup (P = 0.51, OR = 1.14, 95% CI = 0.78–1.67). The average level of lymphocyte count was the lowest with blood type A in patients, however, compared with other blood types, there was still no significant statistical difference. Conclusions: Our findings provide epidemiological evidence that females with blood type A are susceptible to COVID-19. However, these research results need to be validated in future studies.Funding Information
- Chinese Universities Scientific Fund
- Health and Family Planning Commission of Hubei Province
This publication has 41 references indexed in Scilit:
- Blood Groups in Infection and Host SusceptibilityClinical Microbiology Reviews, 2015
- Association of ABO blood group and P. falciparum malaria related outcomes: A cross-sectional study in EthiopiaActa Tropica, 2012
- Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort ConsortiumCancer Research, 2010
- Variation in the host ABO blood group may be associated with susceptibility to hepatitis C virus infectionEpidemiology and Infection, 2009
- ABO genotype and risk of thrombotic events and hemorrhagic strokeJournal of Thrombosis and Haemostasis, 2009
- Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodiesGlycobiology, 2008
- A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)PLoS Genetics, 2008
- Animal Origins of the Severe Acute Respiratory Syndrome Coronavirus: Insight from ACE2-S-Protein InteractionsJournal of Virology, 2006
- HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivationBlood, 2005
- ABO Blood Group and Susceptibility to Severe Acute Respiratory SyndromeJAMA, 2005