Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed Tomography
Open Access
- 1 January 2012
- journal article
- research article
- Published by Hindawi Limited in Journal of Osteoporosis
- Vol. 2012, 1-6
- https://doi.org/10.1155/2012/129760
Abstract
The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sexes, which may help to explain the lower fracture incidence in older men relative to women. This review will highlight observations from these studies on both the sex- and age-related differences in trabecular and cortical microstructure that may underlie the differences in bone strength, and thereby fracture risk, between men and women.Keywords
Funding Information
- National Institutes of Health (AR027065, AG004875)
This publication has 22 references indexed in Scilit:
- Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCTBone, 2010
- Rapid growth produces transient cortical weakness: A risk factor for metaphyseal fractures during pubertyJournal of Bone and Mineral Research, 2010
- Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibiaBone, 2010
- Bone microstructure at the distal tibia provides a strength advantage to males in late puberty: An HR-pQCT studyJournal of Bone and Mineral Research, 2010
- Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibiaJournal of Bone and Mineral Research, 2010
- Bone Structure at the Distal Radius During Adolescent GrowthJournal of Bone and Mineral Research, 2009
- Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone qualityMedical Engineering & Physics, 2007
- In vivo reproducibility of three-dimensional structural properties of noninvasive bone biopsies using 3D-pQCTJournal of Bone and Mineral Research, 1996
- Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committeeJournal of Bone and Mineral Research, 1987
- Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss.JCI Insight, 1983