Female-to-Male Patients Have High Prevalence of Unsatisfactory Paps Compared to Non-Transgender Females: Implications for Cervical Cancer Screening
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- 15 January 2014
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of General Internal Medicine
- Vol. 29 (5), 778-784
- https://doi.org/10.1007/s11606-013-2753-1
Abstract
Little is known about whether and how screening for cancers of natal reproductive structures, including cervical cancer, in female-to-male (FTM) transgender individuals differs from cancer screening among non-transgender females. To investigate anecdotal reports from clinicians of high rates of inadequate Papanicolaou (Pap) tests among transgender men. Results of Pap tests performed on 233 FTM and 3,625 female patients at an urban community health center between 2006 and 2012 were extracted from an electronic medical record. Compared to female patients, FTM patients were more likely to have an inadequate Pap, with prevalence of inadequate samples 8.3 times higher among tests of FTM patients (10.8 % vs. 1.3 % of tests). FTM patients had over ten times higher odds of having an inadequate Pap after adjusting for age, race, and body mass index (AOR = 10.77, 95 % CI = 6.83, 16.83). When years on testosterone therapy was added to the model, the relationship between transgender identity and Pap inadequacy was attenuated, but remained strongly associated (AOR = 6.01, 95 % CI = 3.00, 11.50), and time on testosterone was also associated (AOR = 1.19, 95 % CI 1.04, 1.36). FTM patients were more likely than females to have had multiple inadequate tests, and had longer latency to follow-up testing. The high unsatisfactory sample prevalence among FTM patients is likely due to a combination of physical changes induced by testosterone therapy and provider/patient discomfort with the exam. Clinicians should receive training in increasing comfort for FTM patients during the exam. FTM patients should be alerted that high rates of inadequate screening may require follow-up testing. Alternatives to repeated Pap testing, such as cytologic reprocessing of inadequate samples or primary human papillomavirus (HPV) DNA screening, should be studied for efficacy and acceptability among FTM patients.Keywords
This publication has 27 references indexed in Scilit:
- High heterogeneity of HIV-related sexual risk among transgender people in Ontario, Canada: a province-wide respondent-driven sampling surveyBMC Public Health, 2012
- The Relationship of Waist Circumference and BMI to Visceral, Subcutaneous, and Total Body Fat: Sex and Race DifferencesObesity, 2011
- The Challenging Pelvic ExaminationJournal of General Internal Medicine, 2011
- Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male TranssexualsThe Journal of Sexual Medicine, 2010
- Age‐specific patterns of unsatisfactory results for conventional Pap smears and liquid‐based cytology: data from two randomised clinical trialsBJOG: An International Journal of Obstetrics and Gynaecology, 2010
- An open-label randomized trial to determine the most effective regimen of vaginal estrogen to reduce the prevalence of atrophic changes reported in postmenopausal cervical smearsMenopause, 2009
- Androgen Receptor Expression in Cervical Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the CervixInternational Journal of Gynecological Pathology, 2008
- Total Laparoscopic Hysterectomy for Female-to-Male TranssexualsObstetrics & Gynecology, 2007
- Papanicolaou smear history in women with low-grade cytology before cervical cancer diagnosisCancer, 2007
- Androgen Receptor Expression in the Cervix of Androgen-Treated Female-to-Male TranssexualsInternational Journal of Gynecological Pathology, 1994