Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease
Open Access
- 1 January 2010
- journal article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 12 (1), R17
- https://doi.org/10.1186/ar2918
Abstract
Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress may have a role in the pathophysiology of fibromyalgia. However, it is still not clear whether oxidative stress is the cause or the effect of the abnormalities documented in fibromyalgia. Furthermore, the role of mitochondria in the redox imbalance reported in fibromyalgia also is controversial. We undertook this study to investigate the role of mitochondrial dysfunction, oxidative stress, and mitophagy in fibromyalgia.Keywords
This publication has 44 references indexed in Scilit:
- Mitochondria and Reactive Oxygen SpeciesHypertension, 2009
- How mitochondria produce reactive oxygen speciesBiochemical Journal, 2008
- The in-depth evaluation of suspected mitochondrial diseaseMolecular Genetics and Metabolism, 2008
- Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ 10 deficiencyThe FASEB Journal, 2008
- Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part IIArthritis & Rheumatism, 2007
- Selective degradation of mitochondria by mitophagyArchives of Biochemistry and Biophysics, 2007
- Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4The EMBO Journal, 2007
- Reversible Inhibition of Mitochondrial Protein Synthesis during Linezolid-Related HyperlactatemiaAntimicrobial Agents and Chemotherapy, 2007
- Human Coenzyme Q10 DeficiencyNeurochemical Research, 2006
- The american college of rheumatology 1990 criteria for the classification of fibromyalgiaArthritis & Rheumatism, 1990