Supercontinuum radiation in fluorescence microscopy and biomedical imaging applications
- 25 January 2019
- journal article
- research article
- Published by Optica Publishing Group in Journal of the Optical Society of America B
- Vol. 36 (2), A139-A153
- https://doi.org/10.1364/josab.36.00a139
Abstract
Compact, high brightness supercontinuum sources have already made a big impact in the fields of fluorescence microscopy and biomedical imaging techniques, such as optical coherence tomography and coherent anti-Stokes Raman scattering. In this review, we provide a brief overview on the generation and properties of supercontinuum radiation for imaging applications. We review specific uses of supercontinuum sources and their potential for bioimaging, but also their limitations and caveats. We conclude with a review of recent advances in UV supercontinuum generation, near-IR microscopy, exciting new potentials for the use of hollow-core PCFs, on-chip supercontinuum generation, and technologies to improve supercontinuum stability for certain applications.Keywords
Funding Information
- H2020 Marie Skłodowska-Curie Actions (722380)
- MedImmune
- Infinitus (China) Ltd.
- Engineering and Physical Sciences Research Council (EP/H018301/1, EP/L015889/1)
- Wellcome Trust (089703/Z/09/Z, 3-3249/Z/16/Z)
- Medical Research Council (MR/K015850/1, MR/K02292X/1)
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