Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes
- 1 January 1992
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 55 (1), 314S-317S
- https://doi.org/10.1093/ajcn/55.1.314s
Abstract
A new disaccharidase inhibitor, AO-128, showed 190–3900-fold more potent inhibition of purified rat small intestine sucrase-isomaltase (S-1) complex and 23–33-fold more potent inhibition of semipurified porcine small intestine disaccharidases than acarbose. AO-128 suppressed elevation of the blood glucose concentration after oral sucrose, maltose, and starch, but not after oral glucose, fructose, and lactose. The chronic addition of AO-128 to the diet produced antiobesity and antidiabetic actions in obese and/or diabetic animals. Undesirable side effects, such as diarrhea and soft feces, were observed only for the first 5–7 d and suppression of intestinal disaccharidase activities was observed even at the end of the experiment, suggesting that the suppressive or delaying effect of AO-128 on elevation of the postprandial blood glucose concentrations is involved in reduction in body weight gain and prevention and/or amelioration of the diabetic state. Thus, AO-128 is useful as an adjunct to the dietary management of obesity and diabetes.This publication has 10 references indexed in Scilit:
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