Fast left prefrontal rTMS acutely suppresses analgesic effects of perceived controllability on the emotional component of pain experience
- 1 January 2011
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pain
- Vol. 152 (1), 182-187
- https://doi.org/10.1016/j.pain.2010.10.018
Abstract
The prefrontal cortex may be a promising target for transcranial magnetic stimulation (TMS) in the management of pain. It is not clear how prefrontal TMS affects pain perception, but previous findings suggest that ventral lateral and medial prefrontal circuits may comprise an important part of a circuit of perceived controllability regarding pain, stress, and learned helplessness. Although the left dorsolateral prefrontal cortex is a common TMS target for treating clinical depression as well as modulating pain, little is known about whether TMS over this area may affect perceived controllability. The present study explored the immediate effects of fast TMS over the left dorsolateral prefrontal cortex on the analgesic effects of perceived pain controllability. Twenty-four healthy volunteers underwent a laboratory pain task designed to manipulate perception of pain controllability. Real TMS, compared with sham, suppressed the analgesic benefits of perceived control on the emotional dimension of pain, but not the sensory/discriminatory dimension. Findings suggest that, at least acutely, fast TMS over the left dorsolateral prefrontal cortex may interrupt the perceived-controllability effect on the emotional dimension of pain experience. Although it is not clear whether this cortical area is directly involved with modulating perceived controllability or whether downstream effects are responsible for the present findings, it appears possible that left dorsolateral prefrontal TMS may produce analgesic effects by acting through a cortical perceived-control circuit regulating limbic and brainstem areas of the pain circuit. Despite evidence that prefrontal TMS can have analgesic effects, fast left prefrontal TMS appears to acutely suppress analgesia associated with perceived-control. This effect may be limited to the emotional dimension of pain experience.Keywords
Funding Information
- National Institute for Neurological Disorders and Stroke
This publication has 50 references indexed in Scilit:
- A Pilot Study Investigating the Effects of Fast Left Prefrontal rTMS on Chronic Neuropathic PainPain Medicine, 2009
- Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the ratStress, 2009
- An efficient and accurate new method for locating the F3 position for prefrontal TMS applicationsBrain Stimulation, 2008
- The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social explorationBehavioural Brain Research, 2008
- Significant analgesic effects of one session of postoperative left prefrontal cortex repetitive transcranial magnetic stimulation: A replication studyBrain Stimulation, 2008
- Development and evaluation of a portable sham transcranial magnetic stimulation systemBrain Stimulation, 2008
- Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fearNeuroscience, 2007
- Anterolateral Prefrontal Cortex Mediates the Analgesic Effect of Expected and Perceived Control over PainJournal of Neuroscience, 2006
- Placebo-Induced Changes in fMRI in the Anticipation and Experience of PainScience, 2004
- Placebo and Opioid Analgesia-- Imaging a Shared Neuronal NetworkScience, 2002