Dopamine receptors in a songbird brain
Open Access
- 20 November 2009
- journal article
- research article
- Published by Wiley in Journal of Comparative Neurology
- Vol. 518 (6), 741-769
- https://doi.org/10.1002/cne.22255
Abstract
Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior. In songbirds, dopamine is released into the striatal song nucleus Area X, and the levels depend on social contexts of undirected and directed singing. This differential release is associated with differential expression of activity‐dependent genes, such as egr1 (avian zenk), which in mammalian brain are modulated by dopamine receptors. Here we cloned from zebra finch brain cDNAs of all avian dopamine receptors: the D1 (D1A, D1B, D1D) and D2 (D2, D3, D4) families. Comparative sequence analyses of predicted proteins revealed expected phylogenetic relationships, in which the D1 family exists as single exon and the D2 family exists as spliced exon genes. In both zebra finch and chicken, the D1A, D1B, and D2 receptors were highly expressed in the striatum, the D1D and D3 throughout the pallium and within the mesopallium, respectively, and the D4 mainly in the cerebellum. Furthermore, within the zebra finch, all receptors, except for D4, showed differential expression in song nuclei relative to the surrounding regions and developmentally regulated expression that decreased for most receptors during the sensory acquisition and sensorimotor phases of song learning. Within Area X, half of the cells expressed both D1A and D2 receptors, and a higher proportion of the D1A‐only‐containing neurons expressed egr1 during undirected but not during directed singing. Our findings are consistent with hypotheses that dopamine receptors may be involved in song development and social context‐dependent behaviors. J. Comp. Neurol. 518:741–769, 2010.Keywords
This publication has 124 references indexed in Scilit:
- D1-like dopamine receptor density in nuclei involved in social behavior correlates with song in a context-dependent fashion in male European starlingsNeuroscience, 2009
- Evidence that dopamine within motivation and song control brain regions regulates birdsong context-dependentlyPhysiology & Behavior, 2008
- Dopamine binds to α2-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata)Journal of Chemical Neuroanatomy, 2008
- Drd4 gene polymorphisms are associated with personality variation in a passerine birdProceedings. Biological sciences, 2007
- Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822Pharmacology Biochemistry and Behavior, 2007
- A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genesProceedings of the National Academy of Sciences of the United States of America, 2006
- Avian brains and a new understanding of vertebrate brain evolutionNature Reviews Neuroscience, 2005
- Autoradiographic localization of DI-like dopamine receptors in the forebrain of male and female Japanese quail and their relationship with immunoreactive tyrosine hydroxylaseJournal of Chemical Neuroanatomy, 1995
- The acetylcholine and catecholamine contents in song control nuclei of zebra finch during song ontogenyDevelopmental Brain Research, 1989
- Two dopamine receptors: Biochemistry, physiology and pharmacologyLife Sciences, 1984