PRESYNAPTIC γ-AMINOBUTYRIC ACID RESPONSES IN THE OLFACTORY CORTEX
- 1 February 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 65 (2), 223-228
- https://doi.org/10.1111/j.1476-5381.1979.tb07822.x
Abstract
1. Potential changes were recorded from the lateral olfactory tract in slices of rat olfactory cortex in vitro at room temperature. 2. Superfused gamma-aminobutyric acid (GABA) usually produced dose-related depolarization of the lateral olfactory tract. Muscimol and 3-aminopropanesulphonic acid appeared more potent depolarizing agents than GABA, and glycine and taurine appeared less potent. Carbachol and glutamate were virtually ineffective. 3. The GABA responses were at least partially Cl- dependent. 4. (+)-Bicuculline and higher concentrations of strychnine antagonized the GABA but not the glycine-induced depolarizations. Paradoxically, responses to high doses of GABA were sometimes potentiated by both bicuculline and strychnine. 5. It is suggested that GABA receptors could occur as widely on nerve terminals as they do postsynaptically in the CNS, where GABA could be involved in the modulation of transmitter output.Keywords
This publication has 23 references indexed in Scilit:
- Axonal GABA-receptors in mammalian peripheral nerve trunksBrain Research, 1978
- PRESYNAPTIC ACTIONS OF β‐AMINOBUTYRIC ACID AND SOME ANTAGONISTS IN A SLICE PREPARATION OF CUNEATE NUCLEUSBritish Journal of Pharmacology, 1978
- Use of 3H-muscimol for GABA receptor studiesNature, 1978
- INTERACTION OF PENTOBARBITONE AND γ‐AMINOBUTYRIC ACID ON MAMMALIAN SYMPATHETIC GANGLION CELLSBritish Journal of Pharmacology, 1978
- Characterization and ionic basis of GABA‐induced depolarizations recorded in vitro from cat primary afferent neurones.The Journal of Physiology, 1978
- Non-synaptic chemical neurotransmissionCellular and Molecular Life Sciences, 1977
- SPASMOGENIC AND POTENTIATING ACTIONS OF SOME AMINO ACIDS ON THE GUINEA‐PIG MYOMETRIUMBritish Journal of Pharmacology, 1977
- INFLUENCE OF NEUROGLIAL TRANSPORT ON THE ACTION OF γ‐AMINOBUTYRIC ACID ON MAMMALIAN GANGLION CELLSBritish Journal of Pharmacology, 1977
- Possible presynaptic inhibition in rat olfactory cortex.The Journal of Physiology, 1976
- The influence of potassium and chloride ions on the membrane potential of single muscle fibresThe Journal of Physiology, 1959