Altering the Activity of Syringomycin E via the Membrane Dipole Potential
- 7 March 2008
- journal article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 24 (7), 2987-2991
- https://doi.org/10.1021/la800206v
Abstract
The membrane dipole potential is responsible for the modulation of numerous biological processes. It was previously shown (Ostroumova, O. S.; Kaulin, Y. A.; Gurnev, P. A.; Schagina, L. V. Langmuir2007, 23, 6889−6892) that variations in the dipole potential lead to changes in the channel properties of the antifungal lipodepsipeptide syringomycin E (SRE). Here, data are presented demonstrating the effect of the membrane dipole potential on the channel-forming activity of SRE. A rise in the dipole potential is accompanied by both an increase in the minimum SRE concentration required for the detection of single channels at fixed voltage and a decrease in the steady-state number of open SRE channels at a given SRE concentration and voltage. These alterations are determined by several factors: gating charge, connected with translocations of lipid and SRE dipoles during channel formation, the bilayer−water solution partitioning of SRE, and the chemical work related to conformational changes during channel formation.Keywords
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